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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NBEAL2 All Species: 8.18
Human Site: T422 Identified Species: 16.36
UniProt: Q6ZNJ1 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6ZNJ1 NP_055990.1 2754 302517 T422 L Q S H G P P T H R L L Q E L
Chimpanzee Pan troglodytes XP_525997 2750 313008 P446 L K S L G Q P P L E L L K E L
Rhesus Macaque Macaca mulatta XP_001094456 2295 260424 K131 T L Y I Q Q L K S K K K E K E
Dog Lupus familis XP_541900 2305 251162 P141 D W P A G P S P G P E E A L V
Cat Felis silvestris
Mouse Mus musculus Q6ZQA0 2742 301906 T421 L Q S H G P P T H R L L Q E L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508701 2269 259447 G105 L S N V E E I G T C S Y I N H
Chicken Gallus gallus XP_421964 2298 259902 I134 L L L V K F F I I L C R N L A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W4E2 3584 396477 E453 V G S A D T E E V N Q L K A V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q19317 2507 281187 Q327 P I K T M P Y Q Q G W T F A T
Sea Urchin Strong. purpuratus XP_785921 3355 375569 S255 I D R L G T P S Q E L I E T L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_182078 2946 321916 S435 M S A A A A A S A L A G E G T
Baker's Yeast Sacchar. cerevisiae P25356 2167 250854
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 47.1 40.2 74.6 N.A. 88 N.A. N.A. 39.7 40.6 N.A. N.A. N.A. 20.7 N.A. 21.1 33.4
Protein Similarity: 100 65.6 56.3 77.1 N.A. 92 N.A. N.A. 53.8 55.7 N.A. N.A. N.A. 36.1 N.A. 37.4 48.8
P-Site Identity: 100 53.3 0 13.3 N.A. 100 N.A. N.A. 6.6 6.6 N.A. N.A. N.A. 13.3 N.A. 6.6 26.6
P-Site Similarity: 100 66.6 20 20 N.A. 100 N.A. N.A. 13.3 6.6 N.A. N.A. N.A. 33.3 N.A. 6.6 53.3
Percent
Protein Identity: N.A. N.A. N.A. 20.6 20.4 N.A.
Protein Similarity: N.A. N.A. N.A. 36.5 36.3 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 25 9 9 9 0 9 0 9 0 9 17 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 9 9 0 0 0 0 % C
% Asp: 9 9 0 0 9 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 9 9 9 9 0 17 9 9 25 25 9 % E
% Phe: 0 0 0 0 0 9 9 0 0 0 0 0 9 0 0 % F
% Gly: 0 9 0 0 42 0 0 9 9 9 0 9 0 9 0 % G
% His: 0 0 0 17 0 0 0 0 17 0 0 0 0 0 9 % H
% Ile: 9 9 0 9 0 0 9 9 9 0 0 9 9 0 0 % I
% Lys: 0 9 9 0 9 0 0 9 0 9 9 9 17 9 0 % K
% Leu: 42 17 9 17 0 0 9 0 9 17 34 34 0 17 34 % L
% Met: 9 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 9 0 0 0 0 0 0 9 0 0 9 9 0 % N
% Pro: 9 0 9 0 0 34 34 17 0 9 0 0 0 0 0 % P
% Gln: 0 17 0 0 9 17 0 9 17 0 9 0 17 0 0 % Q
% Arg: 0 0 9 0 0 0 0 0 0 17 0 9 0 0 0 % R
% Ser: 0 17 34 0 0 0 9 17 9 0 9 0 0 0 0 % S
% Thr: 9 0 0 9 0 17 0 17 9 0 0 9 0 9 17 % T
% Val: 9 0 0 17 0 0 0 0 9 0 0 0 0 0 17 % V
% Trp: 0 9 0 0 0 0 0 0 0 0 9 0 0 0 0 % W
% Tyr: 0 0 9 0 0 0 9 0 0 0 0 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _